Signs of CIPA are present from infancy. Infants may present with seizures related to hyperthermia. Because people with this condition are unable to sweat, they are unable to regulate their body temperature. Those affected are unable to feel pain and temperature, but retain the ability to feel touch. Lack of pain puts those with CIPA at a high risk for accidental self-mutilation. Joint and bone problems are common due to repeated injuries, and wounds heal poorly.
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